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TTFields is an innovative treatment modality approved for both newly diagnosed and recurrent GBM in US, Europe and Japan. The mechanism of action has relevance in other cancers. Novocure continues to explore the use of TTFields in a number of cancers of the central nervous system including brain metastases from non-small cell lung cancer (NSCLC) in the ongoing phase III METIS trial.

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TTFields therapy provides clinical versatility that has the potential to help address treatment challenges across a range of solid tumors. To learn more about Tumor Treating Fields therapy and its multifaceted effect on cancer cells, visit tumortreatingfields.usando.

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Figure 2: Effects of TTFields on replicating cells. TTFields exert directional forces on polar microtubules and interfere with the assembly of the normal mitotic spindle and subsequently trigger mitotic cell death.

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Unlike systemic cancer therapies, TTFields only act against rapidly dividing cancer cells while the transducer arrays are adhered to the scalp and TTFields are active. Consequently, the average daily usage of the device (or treatment compliance) is a crucial component of clinical benefit.